Born to David and Beth Holloway, in Clinton Mississippi, Natalie was one of three children. In 1993, David and Beth divorced. Natalee’s mother raised her and her youngest brother. Beth remarried in 2000 to a man named George Tweety, becoming Beth Tweety in the process. She and the kids moved to Mountain Brook, Alabama, where George lived. Despite the difficult of being raised in a home in a strange place with a new parent, Natalee thrived in her new school. She was a member of the National Honor Society and the dance squad.